Systemic Review of Screening the Shapes of Ibuprofen Particles in Different Solvents

Ibuprofen is a very popular analgesic which mostly available in the market as tablet dosage form. The ibuprofen molecule possesses chiral center propionic acid group. So, there are two enantiomers (R and S), whose chemical properties similar, but have optical rotations of opposite sign. (-) form (l- or laevo-) R enantiomer whereas (+) (d dextro-) referred to S – ibuprofen. isomer biologically inactive while active. however slowly converted active during metabolism human body by presence enzyme isomerase (2-arylpropionyl-CoA epimerase). Thus, large difference potency between not found.
 During manufacturing tablet, particle plays significant role flowability compressibility etc. Theoretically size shape great impact on those sorts mechanical tablets. morphology can influence physical such packing density, bulk agglomeration, dissolution behaviour well strength wet ability. Furthermore, crystal shapes also been found an effect bioavailability resulting APIs. Commercial typically has needle shaped with rough surfaces show poor flowability, compaction behavior tendency stick punches. To overcome these problems, suitable desirable that could be directly compressed fewer operation steps still having good product stability therapeutic efficacy, it changed through recrystallization other methods spray drying, crystallized from solvents high hydrogen bonding ability like methanol will chunky crystals low hexane crystals. Therefore, was necessary review particles different solvents.
 This paper covered comprehensive studies cosolvents.